Oral sulfon-cilag in the treatment of leprosy.

It is common knowledge that, in the modern treatment of leprosy, disubstituted derivatives of diaminodiphenyl sulfone (Promanide, Solapsone, Sulphonal sodium) have to a great extent been replaced by the parent substance (DDS). The monosubstituted derivatives have also been shown to be effective (1). Floch and associates (4) concluded that succinyaldiaminodiphenyl sulfone (1500F) owed its therapeutic activity principally to its unchanged molecule. They (5) investigated another monosubstituted derivative, aminohydroxyethylaminodiphenyl sulfone (1087 MM), and found similar therapeutic activity; this substance is found unchanged in the blood, and is partly excreted unchanged in the urine. Herrera (6) believed that Propriosulphone was preferable to DDS for the treatment of infectious cases of leprosy, although 93 per cent of it is eliminated in the urine in the first 24 hours. The monosubstituted sulfones so far investigated are safe and effective in the treatment of leprosy (1), but more evidence is needed before their final therapeutic value can be assessed.